Reaktion #2498296

ord-612a3f3053514aafb41c46755b5f4ec2

Reaktionsgleichung

COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)N[C@H]4CC[C@@H](N)CC4)c(C)[nH]c23)cc1F.Cl
N-(cis-4-aminocyclohexyl)-7-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide hydrochloride
CC(=O)O[C@@H](C)C(=O)Cl
(2S)-1-chloro-1-oxopropan-2-yl acetate
→
COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)N[C@H]4CC[C@@H](NC(=O)[C@H](C)OC)CC4)c(C)[nH]c23)cc1F
title compound
COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)N[C@H]4CC[C@@H](NC(=O)[C@H](C)OC)CC4)c(C)[nH]c23)cc1F
7-[2-(Cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-N-(cis-4-{[(2S)-2-methoxypropanoyl]amino}cyclohexyl)-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

Edukte

COc1cc(OCC2CC2)c(-c2ccnc3c(C(=O)N[C@H]4CC[C@@H](N)CC4)c(C)[nH]c23)cc1F.Cl
N-(cis-4-aminocyclohexyl)-7-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide hydrochloride
CC(=O)O[C@@H](C)C(=O)Cl
(2S)-1-chloro-1-oxopropan-2-yl acetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Starting from N-(cis-4-aminocyclohexyl)-7-[2-(cyclopropylmethoxy)-5-fluoro-4-methoxyphenyl]-2-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide hydrochloride (example D.f28) and commercially available (2S)-1-chloro-1-oxopropan-2-yl acetate the title compound is obtained as colorless solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08816085B2uspto-grants-2014_08