Reaktion #2497373

ord-54f85e5ee47e4244b8d148107b35df8c

Reaktionsgleichung

CCC(=O)N1CCC(CO)CC1
1-(4-(hydroxymethyl)piperidin-1-yl)propan-1-one
N#Cc1c(N)cccc1F
2-amino-6-fluorobenzonitrile
→
CCC(=O)N1CCC(COc2cccc(N)c2C#N)CC1
2-amino-6-((1-propionylpiperidin-4-yl)methoxy)benzonitrile

Edukte

CCC(=O)N1CCC(CO)CC1
1-(4-(hydroxymethyl)piperidin-1-yl)propan-1-one
N#Cc1c(N)cccc1F
2-amino-6-fluorobenzonitrile

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared as in Example 22a from 1-(4-(hydroxymethyl)piperidin-1-yl)propan-1-one (Example 21c) and 2-amino-6-fluorobenzonitrile as a pale-yellow solid (15%). MS 288 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08815956B2uspto-grants-2014_08