Reaktion #2496161

Reaktionsgleichung

4-chloro-6-tert-butylfuro[2,3-d]pyrimidine

3-amino-5-tert-butylselenophene-2-carboxamide

DMF NaOH

→

title compound

3-(6-tert-Butylfuro[2,3-d]pyrimidin-4-ylamino)-5-tert-butylselenophene-2-carboxamide

Reaktionsbedingungen

Vorschrift

The reaction of 4-chloro-6-tert-butylfuro[2,3-d]pyrimidine with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as an off-white color solid, mp 288-290° C. IR (KBr) vmax 3491, 3325 2964, 1593, 1388, 1354, 1314, 1287, 1149, 1119, 1089, 936, 806, 773 cm−1; 1H NMR (400 MHz, DMSO-d6): δ 10.80 (1H, s, exchangeable with D2O), 8.46 (2H, s), 7.48 (2H, br s, exchangeable with D2O), 6.41 (1H, s), 1.39 (9H, s), 1.36 (9H, s); 13C NMR (100 MHz, DMSO-d6): δ 167.4, 167.1, 166.0, 164.1, 152.6, 152.3, 144.9, 121.0, 113.1, 103.3, 94.8, 36.4, 32.7, 32.2, 28.23; LC-MS (negative ion mode): m/z 417, 419 (M−H)−.

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