Reaktion #2496159

Reaktionsgleichung

4-chloro-6-phenylfuro[2,3-d]pyrimidine

3-amino-5-tert-butylselenophene-2-carboxamide

DMF NaOH

→

title compound

3-(6-phenylfuro[2,3-d]pyrimidin-4-ylamino)-5-tert-butylselenophene-2-carboxamide

Reaktionsbedingungen

Vorschrift

The reaction of 4-chloro-6-phenylfuro[2,3-d]pyrimidine with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as a pale yellow color solid, mp 280-282° C. IR (KBr) v. 3326, 3188, 2953, 1624, 1386, 1358, 1324, 1283, 1150, 1089, 1016, 921, 822, 778, 755 cm−1; 1H NMR (400 MHz, DMSO-d6): δ 11.94 (1H, s, exchangeable with D2O), 8.53 (1H, s), 8.50 (1H, s), 7.96 (2H, d, J=7.2 Hz), 7.43-7.55 (5H, m), 7.32 (1H, s), 1.40 (9H, s); 13C NMR (100 MHz, DMSO-d6): δ 167.4, 167.1, 166.2, 153.3, 152.5, 152.3, 144.7, 129.3, 129.1, 128.6, 124.7, 121.1, 113.3, 104.4, 97.4, 36.4, 32.2; LC-MS (negative ion mode): m/z 437, 439 (M−H)−.

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