Reaktion #2496153

Reaktionsgleichung

4-chloropyridino[2,3-d]pyrimidine

3-amino-5-tert-butylselenophene-2-carboxamide

DMF NaOH

→

title compound

5-tert-Butyl-3-(pyridino[2,3-d]pyrimidin-4-ylamino)selenophene-2-carboxamide

Reaktionsbedingungen

Vorschrift

The reaction of 4-chloropyridino[2,3-d]pyrimidine with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as a yellow color solid, mp 222-224° C. IR (KBr) vmax 3310, 3180, 2961, 1616, 1572, 1383, 1332, 1316, 1280, 1245, 1226, 1090 cm−1; 1H NMR (400 MHz, CDCl3+DMSO-d6): δ 9.10 (1H, dd, J=4.4, 1.6 Hz), 8.96 (1H, s), 8.81 (1H, s), 8.55 (1H, dd, J=8.4, 1.6 Hz), 7.54 (1H, dd, J=8.4, 4.4 Hz), 6.50 (2H, br s), 1.48 (9H, s); 13C NMR (100 MHz, CDCl3+DMSO-d6): 168.6, 168.3, 158.6, 157.9, 156.5, 155.8, 146.1, 131.3, 121.9, 121.1, 111.7, 110.3, 36.8, 32.2; LC-MS (negative ion mode): m/z 372, 374 (M−H)−.

Quelle