Reaktion #2496125

ord-4219537690a0490f8c6a6709a296dbd8

Reaktionsgleichung

Clc1ncnc2ncccc12
4-chloropyrido[2,3-d]pyrimidine
CC(C)(C)c1cc(N)c(C(N)=O)[se]1
5-tert-butyl-3-aminoselenophene-2-carboxamide
→
CC(C)(C)c1cc(Nc2ncnc3ncccc23)c(C(N)=O)[se]1
5-(tert-butyl)-3-(pyridino[3,2-e]pyrimidin-4-ylamino)selenophene-2-carboxamide

Edukte

Clc1ncnc2ncccc12
4-chloropyrido[2,3-d]pyrimidine
CC(C)(C)c1cc(N)c(C(N)=O)[se]1
5-tert-butyl-3-aminoselenophene-2-carboxamide

Reagenzien

Keine

Lösungsmittel

CC(C)O
isopropyl alcohol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

As shown in scheme G, 4-chloropyrido[2,3-d]pyrimidine (Robins, R. K. et. al., J. Am. Chem. Soc., 1955, 77, 2256-2260) is reacted with 5-tert-butyl-3-aminoselenophene-2-carboxamide in a protic solvent such as isopropyl alcohol to yield 5-(tert-butyl)-3-(pyridino[3,2-e]pyrimidin-4-ylamino)selenophene-2-carboxamide.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08815879B2uspto-grants-2014_08