Reaktion #2493334

ord-ca8d7dcf84a34172a0b2700a4c87c9cb

Reaktionsgleichung

$CCCN(CCC)C(=O)COC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester

succinic acid

→

$CCCN(CCC)C(=O)COC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1.O=C(O)CCC(=O)O$

3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester succinate salt

Edukte

$CCCN(CCC)C(=O)COC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester

succinic acid

Reagenzien

Keine

Lösungsmittel

2-propanol

Reaktionsbedingungen

Temperatur

20°CELSIUS

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
FiltrationThe resulting suspension was filtered

Vorschrift

0.536 g of 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester (may be prepared as in Preparation 1) and 0.12 g succinic acid were dissolved in 15.25 g 2-propanol at 50° C. in a magnetically stirred glass vial. The solution was cooled to 20° C. and then stirred at this temperature overnight. The resulting suspension was filtered.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08809340B2uspto-grants-2014_08