Reaktion #2487446

Reaktionsgleichung

2-amino-4-(trifluoromethyl)benzamide

4-chlorobenzaldehyde

→

2-(4-Chlorophenyl)-7-trifluoromethyl-3H-quinazolin-4-one

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was then heated
2. 2
   Temperaturat reflux for 24 h
3. 3
   Sonstigethe precipitate was isolated by vacuum filtration
4. 4
   Waschenwashing with water (3×500 mL)
5. 5
   Sonstigedried under vacuum (10 mbar, 50° C.)
6. 6
   Sonstige3.7 min, 325 (M+)

Vorschrift

To a stirred suspension of 2-amino-4-(trifluoromethyl)benzamide (33.6 g, 0.16 mol) in water (750 mL) was added dropwise 4-chlorobenzaldehyde. Iron trichloride hexahydrate (133 g) was then added in portions. The reaction mixture was then heated at reflux for 24 h. After allowing the suspension to cool to room temperature, the precipitate was isolated by vacuum filtration washing with water (3×500 mL) and dried under vacuum (10 mbar, 50° C.). Yield=50 g, 94%; HPLC-mass spectrometry (LC-MS): 3.7 min, 325 (M+).

Quelle