Reaktion #2484579

ord-e9e17355efed46dbb1bcd0a03d1b52df

Reaktionsgleichung

O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2F)cc1
4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid
NC1CCCCC1
cyclohexylamine
O=C(O)CCC(O)c1ccc(-c2ccc(Cl)cc2F)cc1
4-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-hydroxy-butyric acid
Ausbeute 69.0%

Lösungsmittel

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogous to Example 25 from 4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid. Yield: 69% of theory; m.p. of the cyclohexylamine salt: 165°-167° C. (from isopropanol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04021479uspto-grants-1977_05