Reaktion #2484553

ord-255bca920dcf4b6c9c62c723f970cb75

Reaktionsgleichung

O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2F)cc1
4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid
NC1CCCCC1
cyclohexylamine
→
O=C(O)CCCc1ccc(-c2ccc(Cl)cc2F)cc1
4-(2'-Fluoro-4'-chloro-4-biphenylyl)-butyric acid
Ausbeute 60.0%

Edukte

O=C(O)CCC(=O)c1ccc(-c2ccc(Cl)cc2F)cc1
4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid
NC1CCCCC1
cyclohexylamine

Reagenzien

Keine

Lösungsmittel

CC(C)O
isopropanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogous to Example 1 from 4-(2'-fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid. yield: 60% of theory. Melting point of the cyclohexylamine salt: 134°-136° C. (from isopropanol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04021479uspto-grants-1977_05