Reaktion #2481

Reaktionsgleichung

methyl 3-(N-vinylformamido)propionate

5-amino-1-pentanol

sodium methoxide

→

N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed by distillation at reduced pressure

Vorschrift

The apparatus of Example 2 was charged with 15.7 grams (0.1 mol) of methyl 3-(N-vinylformamido)propionate, 10.3 grams (0.1 mol) of 5-amino-1-pentanol and 0.12 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 3 hours after which the methanol coproduct was removed by distillation at reduced pressure. NMR analysis of the remaining amber liquid indicated about 69% conversion to the desired product.

Quelle