Reaktion #2479772

Reaktionsgleichung

hydrogen

charcoal

4-(5-benzyloxypyrimidin-2-yl)benzaldehyde

sodium carbonate

→

4-(5-hydroxypyrimidin-2-yl)benzaldehyde

Ausbeute 88.5%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe inorganic material was filtered off over Sillit
2. 2
   Einengenthe filtrate was concentrated
3. 3
   SonstigeRecrystallization of the crude product from hexane

Vorschrift

A mixture of 10.0 g of 4-(5-benzyloxypyrimidin-2-yl)benzaldehyde, 0.2 g of sodium carbonate and 250 ml of ethyl acetate was treated with 1.0 g of palladium on active charcoal (10%) and hydrogenated at normal pressure and room temperature until the hydrogen uptake came to a standstill. The inorganic material was filtered off over Sillit and the filtrate was concentrated. Recrystallization of the crude product from hexane gave 6.1 g of pure 4-(5-hydroxypyrimidin-2-yl)benzaldehyde.

Quelle