Reaktion #2477488

ord-335a4c3fd2ee4462ab3d4b7633f72d2d

Reaktionsgleichung

CCNCC
diethylamine
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
Intermediate 253
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
4-bromo-N-butyl-2-(isopropylsulfonyl)-N-methylbenzamide
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
Intermediate 242
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
→
CCN(CC)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
title compound
Ausbeute 81.0%
CCN(CC)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
4-bromo-N,N-diethyl-2-(isopropylsulfonyl)benzamide
Ausbeute 81.0%

Edukte

CCNCC
diethylamine
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
Intermediate 253
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
4-bromo-N-butyl-2-(isopropylsulfonyl)-N-methylbenzamide
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
Intermediate 242
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the general method as outlined in Intermediate 253, starting from 4-bromo-2-(isopropylsulfonyl)benzoic acid (Intermediate 242) and diethylamine, the title compound was obtained as a pink solid in 81% yield.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08273769B2uspto-grants-2012_09