Reaktion #2477486

ord-79a4435221c54fa48ffca39cf966f486

Reaktionsgleichung

CNC
dimethylamine
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
Intermediate 253
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
4-bromo-N-butyl-2-(isopropylsulfonyl)-N-methylbenzamide
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
Intermediate 242
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
→
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)N(C)C
title compound
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)N(C)C
4-bromo-2-(isopropylsulfonyl)-N,N-dimethylbenzamide

Edukte

CNC
dimethylamine
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
Intermediate 253
CCCCN(C)C(=O)c1ccc(Br)cc1S(=O)(=O)C(C)C
4-bromo-N-butyl-2-(isopropylsulfonyl)-N-methylbenzamide
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
Intermediate 242
CC(C)S(=O)(=O)c1cc(Br)ccc1C(=O)O
4-bromo-2-(isopropylsulfonyl)benzoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the general method as outlined in Intermediate 253, starting from 4-bromo-2-(isopropylsulfonyl)benzoic acid (Intermediate 242) and dimethylamine, the title compound was obtained as a pink solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08273769B2uspto-grants-2012_09