Reaktion #2477484

Reaktionsgleichung

methyl 4-bromo-2-(isopropylsulfonyl)benzoate

Intermediate 242

methyl 4-bromo-2-(isopropylsulfonyl)benzoate

NaOH

HCl

→

title compound

Ausbeute 78.1%

4-bromo-2-(isopropylsulfonyl)benzoic acid

Ausbeute 78.1%

Lösungsmittel

THF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe reaction mixture was extracted 3 times with EtOAc
2. 2
   TrocknenThe combined organic phases were dried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated to dryness

Vorschrift

A solution of methyl 4-bromo-2-(isopropylsulfonyl)benzoate (Intermediate 242; 516 mg; 1.61 mmol) in THF (10 ml) was treated with a 5 N solution of NaOH in water (4 mL) and the reaction mixture was heated at 60° C. for 1 day. The reaction mixture was acidified with aqueous HCl and the reaction mixture was extracted 3 times with EtOAc. The combined organic phases were dried over MgSO4, filtered and concentrated to dryness affording the title compound as a pale yellow solid (386 mg; 78%).

Quelle