Reaktion #2477109

Reaktionsgleichung

2-(2-ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)propanenitrile

ammonia ethanol

→

title compound

Ausbeute 98.3%

2-(2-ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)propan-1-amine

Ausbeute 98.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGfurther stirred at 40° C. for 3 hr
2. 2
   FiltrationThe catalyst was filtered through celite
3. 3
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

A mixture of 2-(2-ethyl-8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)propanenitrile (185 mg, 0.767 mmol), Raney cobalt (1.9 g) and 2M ammonia/ethanol solution (15 mL) was stirred at room temperature for 12 hr under a hydrogen atmosphere, and further stirred at 40° C. for 3 hr. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (185 mg, yield 98%).

Quelle