Reaktion #2477049

Reaktionsgleichung

furo[3,2-c]pyridine

→

title compound

Ausbeute 72.0%

2,3-dihydrofuro[3,2-c]pyridine

Ausbeute 72.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
4. 4
   workup.ADDITIONsaturated aqueous sodium hydrogen carbonate solution was added
5. 5
   Extraktionthe mixture was extracted with ethyl acetate
6. 6
   TrocknenThe extract was dried over anhydrous sodium sulfate
7. 7
   Sonstigethe solvent was evaporated under reduced pressure

Vorschrift

To a solution of furo[3,2-c]pyridine (500 mg, 4.20 mmol) in acetic acid (8 mL) was added 5% palladium-carbon powder (manufactured by WAKO, 250 mg), and the mixture was stirred at room temperature for 24 hr under a hydrogen atmosphere. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, saturated aqueous sodium hydrogen carbonate solution was added, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (365 mg, yield 72%).

Quelle