Reaktion #2475521

ord-d4f170257c034f5bbc152a894f35828a

Reaktionsgleichung

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(c2cccc(=O)[nH]2)CC1
6-(4-oxo-cyclohexyl)-1H-pyridin-2-one
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(c3cccc(=O)[nH]3)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(c3cccc(=O)[nH]3)CC2)C1
N-({1-[4-(6-Oxo-1,6-dihydro-pyridin-2-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compounds were prepared as white solids from the reductive amination of 6-(4-oxo-cyclohexyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide using the procedure described in Step F of Example 1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08269015B2uspto-grants-2012_09