Reaktion #2470641

Reaktionsgleichung

1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate

2-(3-isocyanatophenoxy)-6-methylpyrazine

→

1-bromo-N-{3-[(6-methylpyrazin-2-yl)oxy]phenyl}-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide

Reaktionsbedingungen

Vorschrift

The compound, 1-bromo-N-{3-[(6-methylpyrazin-2-yl)oxy]phenyl}-3,6,8,9-tetrahydro-7H-pyrazolo[3,4-c][2,7]naphthyridine-7-carboxamide was prepared using 1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate and 2-(3-isocyanatophenoxy)-6-methylpyrazine as described in general procedure M. Yellow solid; M.p.=221-223° C.; 400 MHz 1H NMR (DMSO-d6) δ: 13.96 (s, 1H), 8.87 (s, 1H), 8.40 (s, 1H), 8.28 (s, 1H), 8.27 (s, 1H), 7.4-7.26 (m, 3H), 6.79-6.74 (m, 1H), 4.76 (s, 2H), 3.82 (t, J=6 Hz, 2H), 3.37 (t, J=6 Hz, 2H), 2.35 (s, 3H); LCMS [M+H]: 479.9.

Quelle