Reaktion #2470640

Reaktionsgleichung

1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate

4-(3-isocyanatophenyl)-2-methylthiazole

→

1-bromo-N-(3-(2-methylthiazol-4-yl)phenyl)-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carboxamide

Reaktionsbedingungen

Vorschrift

The compound 1-bromo-N-(3-(2-methylthiazol-4-yl)phenyl)-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carboxamide was prepared using 1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate and 4-(3-isocyanatophenyl)-2-methylthiazole as described in general procedure M and was obtained as a pale yellow solid (0.025 g, 15%). M.p.=258-261° C.; 400 MHz 1H NMR (DMSO-d6) δ: 13.96 (s, 1H), 8.87 (s, 1H), 8.42 (s, 1H), 8.05 (m, 1H), 7.82 (m, 1H), 7.56-7.48 (m, 2H), 7.32-7.26 (m, 1H), 4.79 (s, 2H), 3.85 (t, J=6 Hz, 2H), 3.39 (t, J=6 Hz, 2H), 2.71 (s, 3H); LCMS [M+H]: 468.

Quelle