Reaktion #2467985

Reaktionsgleichung

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

Ausbeute 65.0%

Methyl 4-aminothiophene-3-carboxylate

Ausbeute 65.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe solution was extracted with chloroform
2. 2
   Waschenthe combined chloroform layer was washed with water, brine
3. 3
   Trocknendried over sodium sulfate
4. 4
   FiltrationThe solution was filtered
5. 5
   Sonstigeevaporated the solvent

Vorschrift

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

Quelle