Reaktion #2467984

Reaktionsgleichung

4-oxo-3-methoxycarbonyltetrahydrothiophene

hydroxylamine hydrochloride

→

title compound

Ausbeute 62.3%

Methyl 4-aminothiophene-3-carboxylate hydrochloride

Ausbeute 62.3%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 1 h
2. 2
   TemperaturThe mixture was then cooled
3. 3
   Sonstigethe solid which separated
4. 4
   Filtrationwas filtered off
5. 5
   Waschenwashed with dry ether

Vorschrift

A mixture of 4-oxo-3-methoxycarbonyltetrahydrothiophene (6.5 g, 40.62 mmol), hydroxylamine hydrochloride (2.84 g, 40.62 mmol) and acetonitrile (30 mL) was stirred under reflux for 1 h. The mixture was then cooled and the solid which separated was filtered off and washed with dry ether to afford the title compound (4.9 g, 62%), mp 192-196° C.

Quelle