Reaktion #2467952

Reaktionsgleichung

L-Ala-L-Phe

pyridine

acetic anhydride

water

→

N-[2-(acetylamino)propionyl]phenylalanine

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resulting mixture is extracted three times with chloroform
2. 2
   WaschenThe organic layer is washed with a saturated aqueous solution of sodium chloride
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent is distilled away under reduced pressure

Vorschrift

L-Ala-L-Phe obtained in Experimental Example 6 (100 mg, 0.423 mmol) is suspended in methylene chloride (10 ml), and pyridine (10 ml) and acetic anhydride (1 ml, 11 mmol) are added to the suspension at room temperature. After stirring at room temperature for 24 hours, water is added and the resulting mixture is extracted three times with chloroform. The organic layer is washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and then the solvent is distilled away under reduced pressure to obtain N-[2-(acetylamino)propionyl]phenylalanine.

Quelle