Reaktion #2452118

Reaktionsgleichung

3-dimethylamino-butyric acid

N-hydroxysuccinimide

dicyclohexyl carbodiimide

4-toluenesulfonic acid monohydrate

→

3-Dimethylamino-butyric acid-(2,5-dioxo-pyrrolidine-1-yl)-ester hydrogentosylate

Lösungsmittel

CH2Cl2

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe obtained urea was filtrated
2. 2
   Sonstigethe solution was evaporated
3. 3
   workup.DISSOLUTIONThe residue, dissolved in 10 ml acetonitrile
4. 4
   workup.ADDITIONwas added
5. 5
   SonstigeThe solvent was evaporated under vacuum
6. 6
   Sonstigethe product was recrystallized from acetonitrile or acetone

Vorschrift

6.55 g (50 mMol) 3-dimethylamino-butyric acid 20 was added to 5.75 g (50 mMol) N-hydroxysuccinimide and 11.05 g (55 mMol) dicyclohexyl carbodiimide in 100 ml CH2Cl2. The reaction mixture was stirred for 16 h at RT. The obtained urea was filtrated and the solution was evaporated. The residue, dissolved in 10 ml acetonitrile, was added under stirring to a solution of 9.51 g (50 mMol) 4-toluenesulfonic acid monohydrate in acetonitrile (30 ml). The solvent was evaporated under vacuum and the product was recrystallized from acetonitrile or acetone.

Quelle