Reaktion #2450368

Reaktionsgleichung

tricyclohexylphosphine

3,5-Dichlorobenzotrifluoride

cyclopropylboronic acid

K3PO4

→

1-chloro-3-cyclopropyl-5-trifluoromethyl-benzene

Ausbeute 87.1%

Reaktionsbedingungen

Vorschrift

3,5-Dichlorobenzotrifluoride (1.10 g, 5.1 mmol) and cyclopropylboronic acid (440 mg, 5.1 mmol) were reacted using K3PO4 (3.8 g, 17.9 mmol), tricyclohexylphosphine (145 mg, 0.51 mmol), Pd(OAc)2 (60 mg, 0.27 mmol) as described in example 100 to give 1-chloro-3-cyclopropyl-5-trifluoromethyl-benzene (980 mg, 87%) after purification by flash chromatography on silica gel.

Quelle