Reaktion #2450071

ord-4d1005b252be46f8b9c2d878ae3b4473

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1cccc(C(=O)OCC(=O)N3CCCCC3)c1)CN2c1ccccc1
tert-Butyl 4-oxo-3-(3-((2-oxo-2-(piperidin-1-yl)ethoxy)carbonyl)benzyl)-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate
Cl
HCl
→
O=C(OCC(=O)N1CCCCC1)c1cccc(CN2CN(c3ccccc3)C3(CCNCC3)C2=O)c1
2-oxo-2-(piperidin-1-yl)ethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Edukte

CC(C)(C)OC(=O)N1CCC2(CC1)C(=O)N(Cc1cccc(C(=O)OCC(=O)N3CCCCC3)c1)CN2c1ccccc1
tert-Butyl 4-oxo-3-(3-((2-oxo-2-(piperidin-1-yl)ethoxy)carbonyl)benzyl)-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate
Cl
HCl
—
solution

Reagenzien

Keine

Lösungsmittel

C1COCCO1
dioxane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenthe reaction mixture was concentrated in vacuo

Vorschrift

To tert-Butyl 4-oxo-3-(3-((2-oxo-2-(piperidin-1-yl)ethoxy)carbonyl)benzyl)-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.17 g, 0.29 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-oxo-2-(piperidin-1-yl)ethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08691836B2uspto-grants-2014_04