Reaktion #2443394

Reaktionsgleichung

1-(2-Chlorophenylsulfonyl)piperizine

6-oxa-bicyclo[3,1,0]hexane

→

Trans-2-(4-(2-chlorophenylsulfonyl)piperazin-1-yl)cyclopentanol

Lösungsmittel

ethyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was purified by prep-HPLC

Vorschrift

1-(2-Chlorophenylsulfonyl)piperizine (1 eq, 0.19 mmol) was dissolved in ethyl alcohol (2 ml), then treated with 6-oxa-bicyclo[3,1,0]hexane (2eq, 0.38 mmol), the reaction solution was heated to 80° C. for 8 hour. The reaction mixture was purified by prep-HPLC. 1H NMR (400 MHz, CHLOROFORM-D) δ ppm 1.36-1.48 (m, 1 H), 1.49-1.74 (m, 3 H), 1.81-2.03 (m, 2 H), 2.52-2.67 (m, 3 H), 2.68-2.78 (m, 2 H), 3.28-3.37 (m, 4 H), 3.99-4.18 (m, 1 H), 7.33-7.42 (m, 1 H), 7.44-7.58 (m, 2 H), 7.98 (d, J=8.21, 1.14 Hz, 1 H); ESI-MS: m/z 345 (m+H)+.

Quelle