Reaktion #2441219

Reaktionsgleichung

aniline

1,4-cyclohexanedione

triethylamine

→

N-(4-hydroxyphenyl)aniline

Ausbeute 27.4%

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereacted in air for 8 hours
2. 2
   workup.ADDITIONwas added
3. 3
   EinengenAfter concentrating the reaction mixture under reduced pressure
4. 4
   Sonstigethe resultant was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1)

Vorschrift

0.93 g of aniline, 2.24 g of 1,4-cyclohexanedione and 1.4 ml of triethylamine were heated with stirring in 15 ml of ethanol at 50° C. to 60° C. and reacted in air for 8 hours. During the reaction, ethanol was added as needed. After concentrating the reaction mixture under reduced pressure, the resultant was purified by silica gel column chromatography (n-hexane:ethyl acetate=3:1) and 0.50 g of N-(4-hydroxyphenyl)aniline was obtained (yield 27.4%).

Quelle