Reaktion #2438517

Reaktionsgleichung

4-chloro-6-o-fluoro phenyl-2-(6-metyl-2-pyridinyl)pyrimidine

sodium methoxide

methanol

sodium

→

4-o-fluorophenyl-6-methoxy-2-(6-methyl-2-pyridinyl)pyrimidine

Lösungsmittel

ethyl acetate

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter the mixture was left
2. 2
   Extraktionextracted
3. 3
   TrocknenAfter the extract was dried over anhydrous magnesium sulfate, it
4. 4
   Einengenwas concentrated under reduced pressure

Vorschrift

To the mixture of 4-chloro-6-o-fluoro phenyl-2-(6-metyl-2-pyridinyl)pyrimidine (1 g) was added sodium methoxide prepared from methanol (10 ml) and metallic sodium (0.1 g). After the mixture was left to stand at room temperature for 1 hour, water (30 ml) and ethyl acetate (100 ml) were added thereto, and then extracted. After the extract was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain 4-o-fluorophenyl-6-methoxy-2-(6-methyl-2-pyridinyl)pyrimidine (0.82 g).

Quelle