Reaktion #2438014

ord-dd83975a837442399baf689bae8362e1

Reaktionsgleichung

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
doxorubicin
→
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
GSH doxorubicin

Edukte

N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1
doxorubicin

Reagenzien

Keine

Lösungsmittel

O.[Cl-].[Na+]
normal saline
O.[Cl-].[Na+]
normal saline

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONSix animals were treated i.v
  2. 2
    workup.ADDITIONthe same animals were treated i.v

Vorschrift

Six animals were treated i.v. in the morning (10 am.) with glutathione g/kg) dissolved in normal saline (total injected volume 1 ml/kg). After 30 minutes, the same animals were treated i.v. with doxorubicin (3 mg/kg) dissolved in normal saline (total injected volume 1 ml/kg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04871528uspto-grants-1989_10