Reaktion #2428

Reaktionsgleichung

Acetic anhydride

formic acid

3-aminobenzoic acid

→

3-(Formylamino)benzoic acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred at r.t. for 1 h
2. 2
   workup.STIRRINGstirring continued overnight
3. 3
   SonstigeThe resultant white precipitate was collected
4. 4
   Waschenwashed with water
5. 5
   Trocknendried in vacuo over P2O5 (15.4 g, 85%)

Vorschrift

Acetic anhydride (76 ml) was added to 98% formic acid (130 ml) and the mixture stirred at r.t. 30 min, then 3-aminobenzoic acid (15 g, 109.5 mmol) added. The mixture was stirred at r.t. for 1 h, then water (1.3 L) added and stirring continued overnight. The resultant white precipitate was collected, washed with water and dried in vacuo over P2O5 (15.4 g, 85%).

Quelle