Reaktion #2415

Reaktionsgleichung

5-(4-methylphenyl)-4,6-dichloropyrimidine

phenyl lithium cyclohexane

→

5-(4-methylphenyl)-4,6-dichloro-2-phenylpyrimidine

Lösungsmittel

ether

Reaktionsbedingungen

Vorschrift

A solution of 5-(4-methylphenyl)-4,6-dichloropyrimidine in ether is cooled at -30° C., and thereto is added dropwise a 1.8M phenyl lithium/cyclohexane solution. The reaction mixture is treated in the same manner as in Reference Example 20-(1) to give 5-(4-methylphenyl)-4,6-dichloro-2-phenylpyrimidine as crystalline powder.

Quelle