Reaktion #2395445

Reaktionsgleichung

2-[3-bromo-5-(3-chloro-4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane

3-fluoro-4-methoxyphenylboronic acid

→

title compound

Ausbeute 51.0%

5-(3-Chloro-4-hydroxyphenyl)-3-(3-fluoro-4-hydroxyphenyl)-4-methylthiophene-2-carbaldehyde

Ausbeute 51.0%

Reaktionsbedingungen

Vorschrift

Starting from 2-[3-bromo-5-(3-chloro-4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane (1.0 g, 2.6 mmol, made in Example 13, Step 1) and substituting 3-fluoro-4-methoxyphenylboronic acid (0.52 g, 3.1 mmol) in place of 3-methoxyphenylboronic acid (Step 2), the title compound (0.26 g, 51%, m.p. 227-29° C.) was synthesized in essentially the same manner as described in Example 1, Steps 2-4.

Quelle