Reaktion #2395438

Reaktionsgleichung

2-[3-bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane

2-[3-Bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane

3-chloro-4-methoxyphenylboronic acid

→

title compound

Ausbeute 36.0%

3-(3-Chloro-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-4-methylthiophene-2-carbaldehyde

Ausbeute 36.0%

Reaktionsbedingungen

Vorschrift

Starting from 2-[3-bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane (1.1 g, 3.0 mmol, made in Example 1, Step 1) and substituting 3-chloro-4-methoxyphenylboronic acid (0.67 g, 3.6 mmol) in place of 3-methoxyphenylboronic acid (Step 2), the title compound (0.20 g, 36%, m.p. 234-36° C.) was synthesized in essentially the same manner as described in Example 1, Steps 2-4.

Quelle