Reaktion #2395436

Reaktionsgleichung

2-[3-bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane

2-[3-Bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane

3-fluoro-4-methoxyphenylboronic acid

→

title compound

Ausbeute 97.0%

3-(3-Fluoro-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-4-methyl-2-thiophenecarbaldehyde

Ausbeute 97.0%

Reaktionsbedingungen

Vorschrift

Starting from 2-[3-bromo-5-(4-methoxyphenyl)-4-methylthien-2-yl]-1,3-dioxolane (1.1 g, 3.0 mmol, made in Example 1, Step 1) and substituting 3-fluoro-4-methoxyphenylboronic acid (0.56 g, 3.3 mmol) in place of 3-methoxyphenylboronic acid (Step 2), the title compound (0.60 g, 97%, m.p. 223-26° C.) was synthesized in essentially the same manner as described in Example 1, Steps 2-4.

Quelle