Reaktion #2395429

Reaktionsgleichung

3-Bromo-5-iodo-4-methylthiophene-2-carbaldehyde

ethylene glycol

→

title compound

Ausbeute 94.3%

2-(3-Bromo-5-iodo-4-methylthien-2-yl)-1,3-dioxolane

Ausbeute 94.3%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was heated
2. 2
   Temperaturat reflux under Dean-Stark conditions for 8 h
3. 3
   WaschenAt this time, the cooled solution was washed with 2.5 N aqueous NaOH (200 mL), water (4×200 mL) and brine (200 mL)
4. 4
   Trocknendried (K2CO3)
5. 5
   Einengenconcentrated in vacuo

Vorschrift

3-Bromo-5-iodo-4-methylthiophene-2-carbaldehyde (27 g, 82 mmol), ethylene glycol (5.9 mL, 110 mmol) and p-toluenesulfonic acid monohydrate (0.50 g, 2.6 mmol) were combined in benzene (200 mL) and the mixture was heated at reflux under Dean-Stark conditions for 8 h. At this time, the cooled solution was washed with 2.5 N aqueous NaOH (200 mL), water (4×200 mL) and brine (200 mL), dried (K2CO3) and concentrated in vacuo to give the title compound (29 g, 94%) as an orange oil.

Quelle