Reaktion #2387248

Reaktionsgleichung

8-methyl-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

isopropylamine

→

2-isopropylamino-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

Ausbeute 95.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeExcess amine was removed in vacuo
2. 2
   Sonstigethe residue was partitioned between ethyl acetate and water
3. 3
   WaschenThe organic phase was washed with saturated sodium bicarbonate
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Einengenconcentrated

Vorschrift

A mixture of 8-methyl-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one (194 mg, 0.81 mmol) and 2 mL of isopropylamine was stirred at room temperature for 15 minutes. Excess amine was removed in vacuo, and the residue was partitioned between ethyl acetate and water. The organic phase was washed with saturated sodium bicarbonate, followed by brine, dried over magnesium sulfate, and concentrated to give 168 mg (95%) of 2-isopropylamino-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, mp 148-149° C.

Quelle