Reaktion #2382005

Reaktionsgleichung

6-acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-propylthieno[2,3-c]pyridine

4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride

oxalate

→

6-acetyl-2-propyl-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine

Ausbeute 38.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction and procedure

Vorschrift

The reaction and procedure were conducted in a similar manner as in Example 24 using 1.7 g of 6-acetyl-3-(2-chloroethyl)-4,5,6,7-tetrahydro-2-propylthieno[2,3-c]pyridine and 1.0 g of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride to give 0.7 g of 6-acetyl-2-propyl-3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine as an oil, m.p. 178°-180° C. (decomposition) as oxalate 1/2hydrate thereof.

Quelle