Reaktion #2380306

Reaktionsgleichung

hydrochloric acid

sodium borohydride

compound

1-Methyl-3,4-Dihydroisoquinoline

sodium hydroxide

→

title compound

Ausbeute 93.9%

1-Methyl-1,2,3,4-Tetrahydroisoquinoline

Ausbeute 93.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to below 5° C.
2. 2
   Extraktionwas extracted from ethyl acetate
3. 3
   TrocknenThe ethyl acetate layer was dried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated under a reduced pressure

Vorschrift

1.76g of sodium borohydride(46 mM) was suspended in 80 ml of ethanol, and 6.48 g of the compound(44.6 mM) prepared in Step 2 above was added thereto. The resultant mixture was stirred at an ambient temperature for an hour and cooled to below 5° C., which was then acidified by adding dilute hydrochloric acid. After making the reaction solution alkaline by adding sodium hydroxide, it was extracted from ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure to give 6.17 g of the title compound as oily substance.

Quelle