Reaktion #2380

Reaktionsgleichung

4-tert-butyl-N-{6-[2-(4-benzyloxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzensulfonamide

→

4-tert-butyl-N-{6-[2-(4-hydroxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzenesulfonamide

Ausbeute 97.9%

Lösungsmittel

ethanol tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeis subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere
2. 2
   Sonstigefor 24 hours
3. 3
   SonstigeThe catalyst is removed by filtration
4. 4
   Einengenthe filtrate is concentrated
5. 5
   SonstigeThe residue is crystallized from ethyl acetate/diisopropyl ether

Vorschrift

A mixture of 4-tert-butyl-N-{6-[2-(4-benzyloxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzensulfonamide (3.95 g), 10% palladium-carbon (1.5 g) and ethanol-tetrahydrofuran (80 ml-80 ml) is subjected to catalytic hydrogenation at room temperature under hydrogen atmosphere (1 atm) for 24 hours. The catalyst is removed by filtration, and the filtrate is concentrated. The residue is crystallized from ethyl acetate/diisopropyl ether to give 4-tert-butyl-N-{6-[2-(4-hydroxyphenoxy)ethoxy]-5-(4-methylphenyl)pyrimidin-4-yl}benzenesulfonamide (3.31 g).

Quelle