Reaktion #2377007

Reaktionsgleichung

4-Bromo-1-chloro-7-isoquinolinesulphonyl chloride

isoquinolinol

N-bromosuccinimide

→

4-bromo-1-(2H)-isoquinolone

Lösungsmittel

MeCN

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas formed
2. 2
   TemperaturAfter heating
3. 3
   Temperaturunder reflux for 3 h
4. 4
   Temperaturthe reaction mixture was cooled in ice
5. 5
   Filtrationthe solid filtered
6. 6
   Waschenwashed with MeCN
7. 7
   Sonstigedried

Vorschrift

4-Bromo-1-chloro-7-isoquinolinesulphonyl chloride ##STR198## A suspension of isoquinolinol (10 g, 68.9 mmol) in MeCN (250 ml) at 50° C., was treated with N-bromosuccinimide (12.6 g, 70.8 mmol) whereupon almost complete solution occurred before a thick white precipitate was formed. After heating under reflux for 3 h, the reaction mixture was cooled in ice and the solid filtered, washed with MeCN, and dried to afford 4-bromo-1-(2H)-isoquinolone (7.6 g, 34.0 mmol).

Quelle