Reaktion #2375062

Reaktionsgleichung

2-[(4-Chlorophenyl)methyl]-6-(dipropylamino)-6,7-dihydrocyclopent[f]isoindole-1,3(2H,5H)-dione

HCl

→

129

2-[(4-Chlorophenyl)methyl]-6-(dipropylamino)-3,5,6,7-tetrahydrocyclopent[f]isoindol-1(2H)-one

Lösungsmittel

HOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification
2. 2
   Wascheneluting with 4:1 hexane/acetone
3. 3
   Sonstigeafforded an oil that
4. 4
   Sonstigerecrystallized from EtOAc/MeOH

Vorschrift

Using procedure 47, 2-[(4-Chlorophenyl)methyl]-6-(dipropylamino)-6,7-dihydrocyclopent[f]isoindole-1,3(2H,5H)-dione (102, 0.59 g, 1.43 mmol) was reduced with Zinc dust (0.94 g, 14.3 mmol) in glacial HOAc (100 mL). Purification using silica gel, eluting with 4:1 hexane/acetone, afforded an oil that was converted to an HCl salt and recrystallized from EtOAc/MeOH to give 129 as a white solid (m.p. 233-234° C.).

Quelle