Reaktion #2375061

Reaktionsgleichung

6-(dipropylamino)-6,7-dihydro-2-[[4-(trifluoromethoxy)phenyl]methyl]cyclopent[f]isoindole-1,3(2H,5H)-dione

6-(Dipropylamino)-6,7-dihydro-2-[[4-(trifluoromethoxy)phenyl]methyl]cyclopent[f]isoindole-1,3(2H,5H)-dione

HCl

→

128

6-(Dipropylamino)-3,5,6,7-tetrahydro-2-[[4-(trifluoromethoxy)phenyl]methyl]cyclopent[f]isoindol-1(2H)-one

Lösungsmittel

HOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigerecrystallized from EtOAc/MeOH

Vorschrift

Using procedure 47, 6-(dipropylamino)-6,7-dihydro-2-[[4-(trifluoromethoxy)phenyl]methyl]cyclopent[f]isoindole-1,3(2H,5H)-dione (107, 0.17 g, 0.37 mmol) was reduced with Zinc dust (0.24 g, 3.7 mmol) in glacial HOAc (10 mL). The resulting solid was converted to an HCl salt and recrystallized from EtOAc/MeOH to give 128 as a white solid (m.p. 210-211° C.).

Quelle