Reaktion #2371781

Reaktionsgleichung

toluene

(2′-(4-fluoro-3-methylphenyl)-[3,3′-bipyridin]-6-yl)methanamine

Cyanogen bromide

i-Pr2NEt

→

6-(2-(4-fluoro-3-methylphenyl)pyridin-3-yl)imidazo[1,5-a]pyridin-3-amine

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigecapped vial
2. 2
   Einengenthe reaction mixture was concentrated
3. 3
   Sonstigepurified by reverse phase preparative HPLC conditions

Vorschrift

Cyanogen bromide (62 mg) in dry acetonitrile (1 mL) was added to a screw capped vial containing a stirring solution of (2′-(4-fluoro-3-methylphenyl)-[3,3′-bipyridin]-6-yl)methanamine.xHCl (120 mg), i-Pr2NEt (0.2 mL) and anhydrous toluene. After 4 h, the reaction mixture was concentrated and purified by reverse phase preparative HPLC conditions provided 6-(2-(4-fluoro-3-methylphenyl)pyridin-3-yl)imidazo[1,5-a]pyridin-3-amine (28 mg).

Quelle