Reaktion #2371237

Reaktionsgleichung

water

5-bromo-6-chloro-pyrimidin-4-ylamine

2-[4-(4-fluoro-3-methyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-ethanol hydrochloride

3-[1-(2-Azetidin-1-yl-ethyl)-2-piperidin-4-yl-1H-imidazol-4-yl]-5-trifluoromethyl-pyridine hydrochloride

Cs2CO3

DMSO

→

2-(2-(1-(6-amino-5-bromopyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   workup.STIRRINGstirred for 15 mins
3. 3
   Filtrationfiltered
4. 4
   Sonstigecollected light yellow solid, which
5. 5
   Waschenwas washed with water
6. 6
   Sonstigedried

Vorschrift

A reaction mixture of 5-bromo-6-chloro-pyrimidin-4-ylamine (370.00 mg; 1.78 mmol; 1.00 eq.), 2-[4-(4-fluoro-3-methyl-phenyl)-2-piperidin-4-yl-imidazol-1-yl]-ethanol hydrochloride (3) (732.67 mg; 1.78 mmol; 1.00 eq.), and Cs2CO3 (2313.40 mg; 7.10 mmol; 4.00 eq.) in DMSO 10 ml, stirred at 100° C. for overnight, cooled, poured into water 60 ml, stirred for 15 mins, filtered, collected light yellow solid, which was washed with water, dried, got title compound, 750 mg, 88.9%.

Quelle