Reaktion #2368244

Reaktionsgleichung

1-{4-[1-(cyclopropylmethyl)-4-ethenyl-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

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title compound

1-{4-[1-(cyclopropylmethyl)-4-ethyl-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was sparged under an atmosphere of hydrogen (1 atm)
2. 2
   FiltrationThe mixture was filtered through Celite
3. 3
   Waschenwashed with ethanol
4. 4
   EinengenThe filtrate was concentrated in vacuo
5. 5
   Sonstigepurified via reverse phase HPLC (5-95% MeCN/water+0.1% TFA)

Vorschrift

To a solution of 1-{4-[1-(cyclopropylmethyl)-4-ethenyl-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione (68 mg, 0.17 mmol) in EtOH (1.7 mL) was added palladium on carbon (10 wt %, 9 mg). The mixture was sparged under an atmosphere of hydrogen (1 atm) and stirred for 18 hours. The mixture was filtered through Celite and washed with ethanol. The filtrate was concentrated in vacuo and purified via reverse phase HPLC (5-95% MeCN/water+0.1% TFA) to provide the title compound: 1H NMR (400 MHz, CDCl3) 7.31-7.43 (m, 6H), 4.65 (s, 2H), 4.53 (d, 2H, J=6.8 Hz), 3.83 (s, 2H), 3.13 (q, 2H, J=7.6 Hz), 3.09 (s, 3H), 1.40-1.48 (m, 1H), 1.26 (t, 3H, J=7.2 Hz), 0.66-0.71 (m, 2H), 0.50-0.54 (m, 2H) ppm. LRMS m/z (M+H) 404.3 found, 404.2 required.

Quelle