Reaktion #2366298

Reaktionsgleichung

6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

( g )

3-Fluoro-4-[3-methyl-4-(2-phenyl-piperazin-1-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol

2,2,5,5-tetramethyl-morpholine

→

title compound

3-Fluoro-4-[3-methyl-4-(2,2,5,5-tetramethyl-morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-phenol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigehowever, in the last step only the THP-protecting group on the pyrazole ring was removed

Vorschrift

The title compound was prepared in analogy to Example 1 steps (d) to (g) starting from 6-(4-benzyloxy-2-fluoro-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid and 2,2,5,5-tetramethyl-morpholine, however, in the last step only the THP-protecting group on the pyrazole ring was removed.

Quelle