Reaktion #2363655

Reaktionsgleichung

4-(piperazine-1-yl)phenol

5-amino-3-(3-fluorophenyl)isoxazol-4-carboxylic acid

1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride

hydroxybenzotriazole

→

required compound

Ausbeute 68.5%

(5-amino-3-(3-fluorophenyl)isoxazol-4-yl)(4-(4-hydroxyphenyl)piperazine-1-yl)methanone

Ausbeute 68.5%

Reaktionsbedingungen

Vorschrift

In a similar manner as described in Example 1, by using dimethylformimide (15 mL), 5-amino-3-(3-fluorophenyl)isoxazol-4-carboxylic acid (409 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol), hydroxybenzotriazole (299 mg, 2.21 mmol) and 4-(piperazine-1-yl)phenol (328 mg, 1.84 mmol), a white solid required compound (483 mg, 1.26 mmol, 68%) was obtained.

Quelle