Reaktion #2363652

Reaktionsgleichung

5-amino-3-(3-fluorophenyl)isoxazol-4-carboxylic acid

1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride

1-(3,4-dichlorophenyl)piperazine

→

required compound

Ausbeute 74.5%

(5-amino-3-(3-fluorophenyl)isoxazol-4-yl)(4-(3,4-dichlorophenyl)piperazine-1-yl)methanone

Ausbeute 74.5%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Vorschrift

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 5-amino-3-(3-fluorophenyl)isoxazol-4-carboxylic acid (409 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3,4-dichlorophenyl)piperazine (425 mg, 1.84 mmol), a white solid required compound (596 mg, 1.37 mmol, 74%) was obtained.

Quelle