Reaktion #2362455

ord-c8c729664cae41a19f9f987239398a62

Reaktionsgleichung

COc1cccc(C(C)(C)C(=O)O)n1
2-(6-methoxy-pyridin-2-yl)-2-methyl-propionic acid
CC(C)(C)C(C(=O)O)C(=O)O
mono-tert-butyl malonic acid
COc1cccc(C(C)(C)C(=O)CC(=O)OC(C)(C)C)n1
title compound
COc1cccc(C(C)(C)C(=O)CC(=O)OC(C)(C)C)n1
4-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeused for the synthesis of Compound PR4
  2. 2
    SonstigeThe resultant was used for the next step without further purification

Vorschrift

The title compound was synthesized from 2-(6-methoxy-pyridin-2-yl)-2-methyl-propionic acid and mono-tert-butyl malonic acid according to the method used for the synthesis of Compound PR4. The resultant was used for the next step without further purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09126931B2uspto-grants-2015_09